STUDIES ON THE EFFECT OF INTRAPERITONEAL AND ORAL ADMINISTRATION OF A TRADITIONAL CHINESE MEDICINE (SHO-saMO-TO) ON THE D-GALACTOSAMINE-INDUCED HEPATffC INJURY OF RATS*

phological changes nor a remarkable decline of the enzyme activities was observed. These results suggest that the prophylaxis with TJ-9 prevents the occurrence ofhepatic injury, and therapeutic treatment improves the pathological changes induced by D-Gal. Comparing the methods of [[:J-9 administration to the rats, intrapcritoneal administration was more eflbctive than oral on the hepatic injury. Enzyme cytochemical chttnges in the liyer could be regarded as a useful hallmark for cstimating the effect of a drug and the degree of hepatic dysfunction, as well as structural changes in the liver tissue. The present study provided morphological and cytochemical evidence supporting the fact that [[:J-9 is eficacious in the treatment of human hepatitis.